A comparison between propofol and thiopentone as induction agents in obstetric anaesthesia

Abstract

Propofol 2.5mg/kg was compared with thiopentone 5mg/kg as an induction agent for elective caesarean section. 206 healthy patients were included in an open randomized study, among whom 104 patients received thiopentone and 102 received propofol. These patients were unpremedicated, after induction dose the maintenance was similar for both groups. Both propofol and thiopentone group produced a rapid and smooth induction of anaesthesia with a low incidence of side effects. Diastolic blood pressure was lower in propofol group during the induction to delivery interval. Other haemodynamic changes were similar for both groups. Respiratory upsets occurred less frequently with propofol (7.8%) than with thiopentone (22.5%), but propofol caused more pain (28.8%) on injection compared to thiopentone. Recovery time was shorter after propofol as evaluated by time to open eyes on commands. There was no significant neonatal depression as assessed by Apgar score. Propofol appears to be a suitable alternative to thiopentone as induction agent for obstetric anaesthesia.