Institute of Traditional Medicine: Recent submissions

Now showing items 21-40 of 93

Predominance of Klebsiella pneumoniae ST14 carrying CTX-M-15 causing neonatal sepsis in Tanzania

Mshana, S. E.; Hain, T.; Domann, E.; Lyamuya, E. F.; Chakraborty, T.; Imirzalioglu, C. (BioMed Central, 2013)

Background: Klebsiella pneumoniae strains expressing ESBLs are a predominant cause of hospital acquired infections. Here we describe the molecular epidemiology of these isolates in a tertiary hospital in Tanzania, ...
Cervical cytological changes in HIV-infected patients attending care and treatment clinic at Muhimbili National Hospital, Dar es Salaam, Tanzania

Mwakigonja, Amos R; Torres, Liset M.; Mwakyoma, Henry A.; Kaaya, Ephata E. (BioMed Central, 2012)

Background: Tanzania is among Sub-Saharan countries mostly affected by the HIV and AIDS pandemic, females being more vulnerable than males. HIV infected women appear to have a higher rate of persistent infection by high ...
Integration of Microfractionation, qNMR and Zebrafish Screening for the In Vivo Bioassay-Guided Isolation and Quantitative Bioactivity Analysis of Natural Products

Bohni, N.; Cordero-Maldonado, M. L.; Maes, J.; Siverio-Mota, D.; Marcourt, L.; Munck, S; Wolfender, J. L.; Kamuhabwa, A.R.; Moshi, M.J.; Esguerra, C.V.; de Witte, P.A.M.; Crawford, A.D. (PLOS ONE, 2013)

Natural products (NPs) are an attractive source of chemical diversity for small-molecule drug discovery. Several challenges nevertheless persist with respect to NP discovery, including the time and effort required for ...
Mammea-type coumarins from Mammea usambarensis Verdc.

Magadula, Joseph J.; Masimba, Pax J.; Tarimo, Rose B.; Msengwa, Zaituni; Mbwambo, Zakariah H.; Heydenreich, Matthias; Breard, Dimitri; Richomme, Pascal (Elsevier, 2014)

Phytochemical investigations of Mammea usambarensis resulted into the isolation a d-tocotrienol (1) and five known mammea-type coumarins (2e6). Their structures were determined by NMR, IR, and LC-MS spectroscopic methods ...
Grand multiparity: is it still a risk in pregnancy?

Mgaya, A.H.; Massawe, S. N.,; Kidanto, H. L.,; Mgaya, H. N (BioMed Central, 2013)

Background: The association of grand multiparity and poor pregnancy outcome has not been consistent for decades. Classifying grand multiparous women as a high-risk group without clear evidence of a consistent association with ...
Evaluation of ethnomedical claims and brine shrimp toxicity of some plants used in Tanzania as traditional medicines

Kapingu, M.C; Moshi, M. J; Mbwambo, Z. H; Nondo, R. S; Masimba, P. J; Kamuhabwa, A. (African Ethnomedicines Network, 2006)

Using information from the literature it has been demonstrated that twenty one (21) plants out of 60 (35%) which are used in traditional medicine, in Tabora region (Western Tanzania), are used elsewhere for the treatment ...
HIV vaccine trial capacity building in Tanzania and Mozambique by continued exploration of optimal DNA priming and MVA boosting strategies

Bakari, M (Muhimbili University of Health and Allied Sciences, 2012)

This programme aimed at consolidating and sustaining the capacity building that European partners have invested in HIV vaccine trial preparations in Tanzania, and at the same time to expand a South-South capacity building ...
Experience of initiating collaboration of traditional healers in managing HIV and AIDS in Tanzania

Uiso, F.; Kayombo, E.; Mahunnah, R. (BMC, 2007)

Collaboration between traditional healers and biomedical practitioners is now being accepted by many African countries south of the Sahara because of the increasing problem of HIV/AIDS. The key problem, however, is how ...
Screening of traditionally used plants for in vivo antimalarial activity in mice

Masimba, P; Innocent, E (PMC, 2009)

Aqueous ethanol (80%) extracts of six plants used traditionally for treatment of malaria, Vepris glomerata (F.Hoffm.) Engl (Rutaceae), Maranthus floribunda (Bak.) F.White (Chrysobalanaceae), Strophanthus eminii Asch. & ...
Larvicidal and Brine Shrimp Activities of Vitex Schiliebenii Extracts and Isolated Phytoecdysteroids on Anopheles gambiae Giles S.S Larvae

Nyamoita, Mokua G.; Ester, Innocent; Zakaria, Mbwambo H.; Wilber, Lwande; Ochola, Bwire J.; Ahmed, Hassanali (Journal of Applied Pharmaceutical Science, 2013)

Acetone, methanol and aqueous extracts of the leaves, stem bark and root bark of Vitex schiliebenii belonging to the family Verbenaceae were evaluated for their larvicidal activity against late 3rd/early 4th Anopheles ...
Time-course effects of Vitex schiliebenii (Varbenaceae) solvent extracts on Anopheles gambiae giles s.s. larvae under simulated semi-field conditions

Nyamoita, Mokua G.; Ahmed, Hassanali; Ester, Innocent; Zakaria, Mbwambo H.; Wilber, Lwande; Ochola, Bwire J. (Novus Natural Science Research, 2013)

Objectives: To determine the growth-disrupting effects of polar phyto-extracts of V. schilibenii on Anopheles gambiae larvae in a simulated semi-field condition and to undertake phytochemical screening of constituents ...
Repellency property of long chain aliphatic methyl ketones against Anopheles gambiae s.s

INNOCENT, E.; GIKONYO, N.K.; NKUNYA, M.H.H. (Tanzania Journal of Health Research, 2008)

Long chain aliphatic methyl ketone series of C7-C15 were tested for repellency activity against the malaria transmitting mosquito Anopheles gambiae s.s. All methyl ketones produced a dose dependent (P<0.001) repellency response ...
Larvicidal activity of Kotschya uguenensis plant powders and methanol extracts against Anopheles gambiae s.s. larvae in the laboratory and in simulated ponds

Innocent, E; Hassanali, A; Nkunya, MHH (Journal of Applied Pharmaceutical Science, 2013)

Polar constituents of Kotschya uguenensis Verdc. (Fabaceae) do not exhibit acute toxicity but cause growth disruption of Anopheles gambiae s.s. Gile (Diptera: Culicidae) larvae with eventual death. Time-course larvicidal effects ...
Antimicrobial and brine shrimp toxicity of some plants used in traditional medicine in Bukoba District, north-western Tanzania

MOSHI, M.J.; URASSA, I.; INNOCENT, E.; MASIMBA1, P.J.; OTIENO2, D.F.; WEISHEIT, A.; MBABAZI, P.; LYNES, M.; MEACHEM, K.; HAMILTON, , A. (Tanzania Journal of Health Research,, 2009)

Herbal medicines constitute a potentially important resource for new and safe drugs for the management of microbial infections and other diseases. In this study, dichloromethane, ethylacetate and ethanol extracts of ...
Growth disruption activity of polar extracts from Kotschya uguenensis (Fabaceae) against Anopheles gambiae s.s. (Diptera: Culicidae) larvae

Innocent, Ester; Joseph, Cosam C.; Gikonyo, Nicholas K.; Nkunya, Mayunga H.H; Hassanali, Ahmed (International Journal of Tropical Insect Science, 2008)

Studies on the larvicidal properties of extracts and fractions from Kotschya uguenensis Verdc. were done by long-term exposure of Anopheles gambiae s.s. larvae. The cumulative mean percentage mortalities and deformities ...
Variations of anti-mosquito larvicidal constituents in the Harrisonia abyssinica species of Tanzania

MAGADULA, J.J.; INNOCENT, E. (Int. J. Biol. Chem. Sci., 2010)

Harrisonia abyssinica (Simaroubaceae) is widely distributed and used in traditional medicine in Tanzania. Phytochemical studies of the plant report the presence of steroid and limonoid compounds while much of its biological ...
Larvicidal properties of some Tanzanian plant species against Anopheles gambiae s.s. Gile (Diptera:Culicidae) mosquitoes

INNOCENT 1, E; COSAM, J C.; GIKONYO, N. K.; NKUNYA, M. H. H.; HASSANALI, A (Int. J. Biol. Chem. Sci., 2009)

Ethnobotanical survey was done among the Hehe community of central Tanzania to identify plants that can be used in the control of malaria transmitting mosquito vectors. Extracts from different plant parts were analysed ...
Antimicrobial and cytotoxic activities of fresh leaf extracts of Warburgia ugandensis

MBWAMBO, Z.H.; ERASTO, P.; MASIMBA, P.J.; INNOCENT, E. (Tanzania Journal of Health Research,, 2009)

Warburgia ugandensis Sprague (Canellaceae), is widely used by Traditional Health Practitioners in Eastern and Southern Africa for treatment of diseases and conditions associated with HIV/AIDS infections. The most commonly ...
Traditional Knowledge, Use Practices and Conservation of Medicinal Plants for HIV/AIDS Care in Rural Tanzania

Kisangau, Daniel P.; Herrmann, Thora Martina; Lyaruu, Herbert V. M.; Masimba, Pax J.; Hosea, Ken M; Joseph, Cosam C.; Mbwambo, Zakaria. H. (2011)

HIV/AIDS pandemic is currently the most socio-economic challenge that faces Tanzania as it affects mostly the young and most economically productive population. People living with HIV/AIDS in Tanzania are susceptible ...
Evaluation of the potential of the marine sponges of the Zanzibar Island to yield antimalarial and antimicrobial active compounds

Said1, S.A.; Guantai, A.N.; Moshi, M.J.; Nondo, R.S.O.; Masimba, P.J.; Innocent, E. (2010)

Emergence of new and re‐emergence of old infections continue to elude prospects of reducing morbidity and mortality caused by microbial infections. Trends of resistance to currently in use antimicrobials and antimalarials ...

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