Abstract:
Midazolam a new intravenous induction agent of the
benzodiazepine class was studied in 120 healthy unpremedicated
patients. These patients were undergoing short diagnostic and
therapeutic procedures lasting less than one hour. The mean duration
of Anaesthesia was 22.63minutes. Rapid smooth induction of
anaesthesia was attained with an induction dose of 0.3mgfkg. with the
mean induction time of 67.82 seconds. Characteristics of concern were
transient apnoea 25.84%, incidence of side effects which was found to
be low and changes in the systolic and diastolic blood pressure which
were found to be significant, but well torelated by these healthy
patients. Haemoglobin levels as well as serum albumin levels were not
shown to have any effect on the induction characteristics of midazolam.
Induction was also associated with short recovery and orientation time.
These were found to have a positive correlation to the duration of
anaesthesia.
