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Autonomic function in a prevalent Tanzanian population with Parkinson’s disease and its relationship to disease duration and 5-year mortality

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dc.contributor.author Ceravolo, R.
dc.contributor.author Rossi, C.
dc.contributor.author Kiferle, L
dc.contributor.author Walker, RW
dc.date.accessioned 2014-11-18T08:24:13Z
dc.date.available 2014-11-18T08:24:13Z
dc.date.issued 2013
dc.identifier.citation Aris, E., Dotchin, C. L., Gray, W. K., & Walker, R. W. (2013). Autonomic function in a prevalent Tanzanian population with Parkinson's disease and its relationship to disease duration and 5-year mortality. BMC research notes, 6(1), 535. en_GB
dc.identifier.other 1756-0500/6/535
dc.identifier.uri http://hdl.handle.net/123456789/1479
dc.description.abstract Background: Autonomic dysfunction is common in patients with Parkinson’s disease (PD). We report autonomic function test results in a prevalent, largely untreated, Tanzanian population of PD patients, at different disease stages and investigate the relationship between autonomic dysfunction and mortality. Methods: Ewing’s battery of autonomic tests was carried out on a prevalent population of PD patients living in the rural Hai district of Tanzania. Where possible, all four tests were performed in the patient’s home. The main outcome of interest was the presence of abnormalities of sympathetic or parasympathetic function. Information on medications used and other co-morbidities was recorded. Results: Autonomic function tests were recorded for 29 subjects, of whom 3 were on medication at the time of assessment. Of the 26 unmedicated patients, 14 (53.8%) had at least one abnormal test result for autonomic function, of whom only 3 (21.4%) were in late stage disease (Hoehn and Yahr stage IV or V), compared to 7 (58.3%) of 12 with normal autonomic function tests in late stage disease. Ten subjects had died at 5-year follow-up, but there was no association between mortality and autonomic function test abnormalities. Conclusions: In unmedicated subjects, many patients in late stage disease had relatively preserved autonomic function, compared to those in early stage disease. In people with PD who are taking medication, it may be that when autonomic dysfunction presents in late stage disease it is often due to side effects of medication rather than the disease itself. en_GB
dc.language.iso en en_GB
dc.publisher BioMed Central en_GB
dc.relation.ispartofseries Research Notes 2013;6:535
dc.subject Parkinson’s disease en_GB
dc.subject Africa en_GB
dc.subject Autonomic function en_GB
dc.title Autonomic function in a prevalent Tanzanian population with Parkinson’s disease and its relationship to disease duration and 5-year mortality en_GB
dc.type Article en_GB


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