Abstract:
Objective: Predictors and consequences of childhood anaemia in settings with high
HIV prevalence are not well known. The aims of the present study were to identify
maternal and child predictors of anaemia among children born to HIV-infected
women and to study the association between childhood anaemia and mortality.
Design: Prospective cohort study. Maternal characteristics during pregnancy and
Hb measurements at 3-month intervals from birth were available for children.
Information was also collected on malaria and HIV infection in the children, who
were followed up for survival status until 24 months after birth.
Setting: Dar es Salaam, Tanzania.
Subjects: The study sample consisted of 829 children born to HIV-positive women.
Results: Advanced maternal clinical HIV disease (relative risk (RR) for stage $2
v. stage 1: 1?31, 95% CI 1?14, 1?51) and low CD4 cell counts during pregnancy (RR
for ,350 cells/mm3 v. $350 cells/mm3: 1?58, 95% CI 1?05, 2?37) were associated
with increased risk of anaemia among children. Birth weight ,2500 g, preterm
birth (,34 weeks), malaria parasitaemia and HIV infection in the children also
increased the risk of anaemia. Fe-deficiency anaemia in children was an independent
predictor of mortality in the first two years of life (hazard ratio 1?99, 95%
CI 1?06, 3?72).
Conclusions: Comprehensive care including highly active antiretroviral therapy to
eligible HIV-infected women during pregnancy could reduce the burden of
anaemia in children. Programmes for the prevention of mother-to-child transmission
of HIV and antimalarial treatment to children could improve child survival
in settings with high HIV prevalence.
