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Predictors and consequences of anaemia among antiretroviral-nave HIV-infected and HIV-uninfected children in Tanzania

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dc.contributor.author Chatterjee, A.
dc.contributor.author Bosch, R.J
dc.contributor.author Kupka, R.
dc.contributor.author Hunter, D.J
dc.contributor.author Msamanga, G.I
dc.contributor.author Fawzi, W.W
dc.date.accessioned 2013-02-08T10:23:01Z
dc.date.available 2013-02-08T10:23:01Z
dc.date.issued 2009
dc.identifier.citation Chatterjee, A., Bosch, R. J., Kupka, R., Hunter, D. J., Msamanga, G. I., & Fawzi, W. W. (2011). Predictors and consequences of anaemia among antiretroviral-nave HIV-infected and HIV-uninfected children in Tanzania.
dc.identifier.issn S1368980009990802
dc.identifier.other doi:10.1017/S1368980009990802
dc.identifier.uri http://hdl.handle.net/123456789/230
dc.description.abstract Objective: Predictors and consequences of childhood anaemia in settings with high HIV prevalence are not well known. The aims of the present study were to identify maternal and child predictors of anaemia among children born to HIV-infected women and to study the association between childhood anaemia and mortality. Design: Prospective cohort study. Maternal characteristics during pregnancy and Hb measurements at 3-month intervals from birth were available for children. Information was also collected on malaria and HIV infection in the children, who were followed up for survival status until 24 months after birth. Setting: Dar es Salaam, Tanzania. Subjects: The study sample consisted of 829 children born to HIV-positive women. Results: Advanced maternal clinical HIV disease (relative risk (RR) for stage $2 v. stage 1: 1?31, 95% CI 1?14, 1?51) and low CD4 cell counts during pregnancy (RR for ,350 cells/mm3 v. $350 cells/mm3: 1?58, 95% CI 1?05, 2?37) were associated with increased risk of anaemia among children. Birth weight ,2500 g, preterm birth (,34 weeks), malaria parasitaemia and HIV infection in the children also increased the risk of anaemia. Fe-deficiency anaemia in children was an independent predictor of mortality in the first two years of life (hazard ratio 1?99, 95% CI 1?06, 3?72). Conclusions: Comprehensive care including highly active antiretroviral therapy to eligible HIV-infected women during pregnancy could reduce the burden of anaemia in children. Programmes for the prevention of mother-to-child transmission of HIV and antimalarial treatment to children could improve child survival in settings with high HIV prevalence. en_GB
dc.language.iso en en_GB
dc.publisher The authors en_GB
dc.relation.ispartofseries Public Health Nutrition;13(2), 289–296
dc.subject HIV en_GB
dc.subject Malaria en_GB
dc.subject Anaemia en_GB
dc.subject Child mortality en_GB
dc.subject Sub-Saharan Africa en_GB
dc.title Predictors and consequences of anaemia among antiretroviral-nave HIV-infected and HIV-uninfected children in Tanzania en_GB
dc.type Article en_GB


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