Abstract:
Background: Fatty liver disease has become an important cause of chronic liver disease
and an alarming public health problem. Several studies around the globe have revealed the
prevalence of fatty liver disease to range between 10% and 63.5%. In recent times, fatty
liver disease has gained global prominence because of its associated increased risk of end stage liver disease, liver failure and hepatocellular carcinoma. In general, patients with
fatty liver disease have increased all-cause mortality and liver-related mortality compared
to the general population thus its prevention, diagnosis, and management is crucial in any
given population. There is limited information regarding fatty liver disease in a Tanzanian
population.
Objective: To determine the prevalence, awareness and associated factors for fatty liver
disease among outpatients at MUHAS Academic Medical Centre.
Methodology: A cross-sectional study conducted from June 2018 to November 2018 at
MUHAS Academic Medical Centre – Dar es Salaam, Tanzania. Consenting patients
attending internal medicine clinics were interviewed, examined and investigated. Socio demographic information, clinical, laboratory, and assessment of awareness about fatty
liver disease parameters were gathered during the interviews. Fatty liver disease was
identified with ultrasound imaging. Continuous variables were compared with the use of
student’s t-test and categorical data with the use of chi-squared test. To assess for
associated factors, we performed logistic regression analyses, p<0.05 was used to denote
significance.
Results: A total of 432 outpatients were enrolled. The prevalence of fatty liver disease was
13.9%. An overwhelming majority of the subjects stated that their physicians did not have
a discussion about fatty liver disease. Independent associated factors of fatty liver disease
were the male gender, having diabetes mellitus, waist circumference >99M/80F, high total
cholesterol >220mg/dl, high triglycerides >170mg/dl, and low HDL < 40mg/dl.
Conclusion: Fatty liver disease is not uncommon among outpatients in Tanzania. A
significant number of people among the general community have never had a discussion
about fatty liver disease with their physician. Factors that were associated with fatty liver
vi
disease in this current setting were similar to the ones reported in several other settings
around the globe. Several strategies to improve health education are vital. Early diagnosis
and timely management of fatty liver disease will certainly improve the quality of life and
its expectancy at large
