Factors associated with uptake of kidney transplantation among patients with end-stage kidney disease attending dialysis centre in Dar es salaam region

Abstract

Background: In Tanzania, kidney transplantation was introduced in November 2017. There is limited information on the factors that associated with uptake of this treatment option within Dar es Salaam. Objectives: This study examined the factors that associated with uptake of kidney transplantation among patients with end-stage kidney disease among patients on dialysis in Dar es Salaam. Methodology: A quantitative hospital-based cross-sectional study was carried among 142 patients with end-stage kidney disease in Dar es Salaam dialysis centre. The data has been summarized at the univariate level by descriptive statistics; comparisons at bivariate level was carried by the non-parametric test, the level of significance set at p = 0.05 (5%). A multivariate logistic regression analysis was done to assess factors affecting the uptake of kidney transplantation. Results: Results showed that most of the participants were knowledgeable and aware of the availability of kidney transplantation. Out of 142 surveyed respondents, 39 (27%) had adequate knowledge, while 72 (51%) had moderate knowledge on kidney transplantation. Furthermore, out of 142, 45 (32%) participants had negative attitudes towards kidney transplantation. The most important factors found to explain participants’ uptake of the kidney transplantation included: cost of the transplantation AOR=0.38 (95% CI, 0.16-0.97, p<0.05), discussion with the physician about kidney transplantation AOR=3.86 (95% CI, 1.18-12.61, p<0.05), and having a positive attitude toward kidney transplantation AOR=2.61 (95% CI, 1.14-5.93, (p<0.05). Conclusion: This study has identified factors influencing patients’ uptake of kidney transplantation. More research is needed to uncover why some of the patients have negative attitude towards kidney transplant will provide crucial information to the clinicians and health management. Information provided will help to advice on how transplantation education/counselling can be tailored towards needs of specific population