Abstract:
Background: Results from HIV vaccine trials on potential volunteers will contribute to global efforts to develop an HIV
vaccine. The purpose of this study among police officers in Dar es Salaam, Tanzania, was to explore the underlying
reasons that induce people to enrol in an HIV vaccine trial.
Methods: We conducted discussions with eight focus groups, containing a total of 66 police officers. The information
collected was analyzed using interpretive description.
Results: The results showed that participants were motivated to participate in the trial by altruism, and that the
participants experienced some concerns about their participation. They stated that altruism in the fight against HIV
infection was the main reason for enrolling in the trial. However, young participants were seriously concerned about a
possible loss of close relationships if they enrolled in the HIV vaccine trial. Both men and women feared the effect of the
trial on their reproductive biology, and they feared interference with pregnancy norms. They were unsure about risks
such as the risks of acquiring HIV infection and of suffering physical harm, and they were unsure of the intentions of the
researchers conducting the trial. Further, enrolling in the trial required medical examination, and this led some
participants to fear that unknown diseases would be revealed. Other participants, however, saw an opportunity to
obtain free health services.
Conclusions: We have shown that specific fears are important concerns when recruiting volunteers to an HIV vaccine
trial. More knowledge is needed to determine participants' views and to ensure that they understand the conduct of
the trial and the reasons it is being carried out.
