Abstract:
Background: Fascial space infections in the orofacial region have plagued humans for centuries. The majority of these infections are
of odontogenic origin and are polymicrobial in nature. This study aimed at determining the clinical and microbiological pattern of
orofacial space infections in patients attending a tertiary hospital in Tanzania.
Methods: This was a cross-sectional hospital-based study that included patients with pyogenic orofacial space infections. Data on the
demographic pattern of the patients, clinical presentations of the disease, and results of culture and sensitivity tests were collected.
For analysis, when more than two spaces were involved, the case was classified as multiple space infection. The number of microbial
isolates was grouped into no isolate, monomicrobial, and polymicrobial. The significance level was set at p <0.05.
Results: The study consisted of 60 patients of whom 51.7% were males. The mean age was 33 ± 17.3 years. A painful swelling was
the chief complaint of the majority of patients. Odontogenic causes of fascial space infection accounted for the majority (81.7%) of the
cases. In most (66.7%) patients, multiple fascial spaces were involved, and the submandibular space was the frequently affected
space. The most frequently isolated microbes were Streptococcus viridans and coagulase-negative Staphylococcus. The drug
susceptibility test of different isolates to antibiotic agents revealed that clindamycin and amoxicillin + clavulanate were effective against
both aerobes and anaerobes.
Conclusions: The young individuals and males were more affected. Most of the fascial space infections affect multiple spaces,
commonly submandibular space. Streptococcus viridans and coagulase-negative Staphylococcus have frequently encountered
isolates. Clindamycin was the most effective drug with a wide spectrum of activity against both aerobes and anaerobes.
