Primary antimicrobial resistance among Mycobacterium tuberculosis isolates from HIV seropositive and HIV seronegative patients in Dar es Salaam Tanzania

Show simple item record

dc.contributor.author Urassa, W.
dc.contributor.author Mugusi, F.
dc.contributor.author Villamor, E.
dc.contributor.author Moshiro, C.
dc.contributor.author Bosch, R.
dc.contributor.author Saathoff, E.
dc.contributor.author Fawzi, W.
dc.date.accessioned 2013-02-13T08:30:05Z
dc.date.available 2013-02-13T08:30:05Z
dc.date.issued 2008
dc.identifier.citation Urassa, W., Mugusi, F., Villamor, E., Msamanga, G., Moshiro, C., Bosch, R., ... & Fawzi, W. (2008). Primary antimicrobial resistance among Mycobacterium tuberculosis isolates from HIV seropositive and HIV seronegative patients in Dar es Salaam Tanzania. BMC research notes, 1(1), 58.
dc.identifier.issn 1756-0500-1-58
dc.identifier.other doi:10.1186/1756-0500-1-58
dc.identifier.uri http://hdl.handle.net/123456789/380
dc.description.abstract Background: The United Republic of Tanzania is one of the 22 high M. tuberculosis burden countries. Data collected between 2002 and 2007 indicate that the global prevalence of drugresistant M. tuberculosis including MDR vary greatly. The varied drug-resistance patterns make continuous surveillance of drug resistance an essential component of tuberculosis control program. Findings: M. tuberculosis isolates were obtained from consenting adult tuberculosis patients involved in a placebo-controlled study to evaluate the efficacy of multivitamin supplements on response to anti-Tb treatment in Dar es Salaam, Tanzania. Antimicrobial susceptibility testing was done on four antimicrobial agents namely streptomycin, isoniazid, ethambutol and rifampicin. HIV testing and CD4+ T lymphocytes enumeration were also done. A total of 280 M. tuberculosis isolates from 191 (68%) males and 89 (32%) female patients with no previous history of antituberculosis treatment exceeding 4 weeks in the previous 12 months were tested. Among these, 133 (47%) patients were HIV seropositive. Fourteen (5.0%) isolates were resistant to any of the anti-tuberculosis drugs. The prevalence of primary resistance was 5.0%, 0.7%, 0.4% and 0% for isoniazid, streptomycin, rifampicin and ethambutol respectively. One isolate (0.4%) was MDR, with resistance to isoniazid, streptomycin and rifampicin. Conclusion: M. Tb primary resistance rate in a selected population in Dar es Salaam Tanzania is low and efforts should be undertaken to support the Tuberculosis program. en_GB
dc.language.iso en en_GB
dc.publisher BioMed Central en_GB
dc.relation.ispartofseries BMC Research Notes;1:58
dc.subject antimicrobial en_GB
dc.subject Mycobacterium en_GB
dc.subject tuberculosis en_GB
dc.subject HIV seronegative en_GB
dc.subject HIV seropositive en_GB
dc.subject Tanzania en_GB
dc.title Primary antimicrobial resistance among Mycobacterium tuberculosis isolates from HIV seropositive and HIV seronegative patients in Dar es Salaam Tanzania en_GB
dc.type Article en_GB


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search MUHAS IR


Advanced Search

Browse

My Account