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Species distribution and in vitro antifungal susceptibility of oral yeast isolates from Tanzanian HIV-infected patients with primary and recurrent oropharyngeal candidiasis

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dc.contributor.author Hamza, O.J.M.
dc.contributor.author Matee, M.I.N.
dc.contributor.author Moshi, M.J.
dc.contributor.author Simon, E.N.M.
dc.contributor.author Mugusi, F.
dc.contributor.author Mikx, F.H.M.
dc.contributor.author Helderman, W.H.P.
dc.contributor.author Rijs, A.J.M.M.
dc.contributor.author van der Ven, A.J.
dc.contributor.author Verweij, P.E.
dc.date.accessioned 2013-02-13T10:26:39Z
dc.date.available 2013-02-13T10:26:39Z
dc.date.issued 2008
dc.identifier.issn 1471-2180-8-135
dc.identifier.uri http://hdl.handle.net/123456789/399
dc.description.abstract Background: In Tanzania, little is known on the species distribution and antifungal susceptibility profiles of yeast isolates from HIV-infected patients with primary and recurrent oropharyngeal candidiasis. Methods: A total of 296 clinical oral yeasts were isolated from 292 HIV-infected patients with oropharyngeal candidiasis at the Muhimbili National Hospital, Dar es Salaam, Tanzania. Identification of the yeasts was performed using standard phenotypic methods. Antifungal susceptibility to fluconazole, itraconazole, miconazole, clotrimazole, amphotericin B and nystatin was assessed using a broth microdilution format according to the guidelines of the Clinical and Laboratory Standard Institute (CLSI; M27-A2). Results: Candida albicans was the most frequently isolated species from 250 (84.5%) patients followed by C. glabrata from 20 (6.8%) patients, and C. krusei from 10 (3.4%) patients. There was no observed significant difference in species distribution between patients with primary and recurrent oropharyngeal candidiasis, but isolates cultured from patients previously treated were significantly less susceptible to the azole compounds compared to those cultured from antifungal naïve patients. Conclusion: C. albicans was the most frequently isolated species from patients with oropharyngeal candidiasis. Oral yeast isolates from Tanzania had high level susceptibility to the antifungal agents tested. Recurrent oropharyngeal candidiasis and previous antifungal therapy significantly correlated with reduced susceptibility to azoles antifungal agents. en_GB
dc.language.iso en en_GB
dc.publisher BioMed Central en_GB
dc.relation.ispartofseries BMC Microbiology;doi:10.1186/1471-2180-8-135
dc.subject Species distribution en_GB
dc.subject in vitro antifungal en_GB
dc.subject oral yeast en_GB
dc.subject HIV-infected patients en_GB
dc.subject oropharyngeal en_GB
dc.subject Tanzania en_GB
dc.title Species distribution and in vitro antifungal susceptibility of oral yeast isolates from Tanzanian HIV-infected patients with primary and recurrent oropharyngeal candidiasis en_GB
dc.type Article en_GB


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