Prenylated Flavonoids from the Root Bark of Berchemia discolor, a Tanzanian Medicinal Plant

Chin, Y.-W.; Mdee, L.K.; Mbwambo, Z.H.; Mi, Q.; Chai, H.-B.; Cragg, G.M.; Swanson, S.M; Kinghorn, A.D.

dc.contributor.author	Chin, Y.-W.
dc.contributor.author	Mdee, L.K.
dc.contributor.author	Mbwambo, Z.H.
dc.contributor.author	Mi, Q.
dc.contributor.author	Chai, H.-B.
dc.contributor.author	Cragg, G.M.
dc.contributor.author	Swanson, S.M
dc.contributor.author	Kinghorn, A.D.
dc.date.accessioned	2013-02-14T09:47:06Z
dc.date.available	2013-02-14T09:47:06Z
dc.date.issued	2006
dc.identifier.uri	http://hdl.handle.net/123456789/442
dc.description.abstract	Five new prenylated flavonoids (1–5) were isolated from the root bark of Berchemia discolor, collected in Tanzania, along with 10 known compounds, by bioactivity-guided fractionation. The structures of compounds (1–5) were elucidated using various spectroscopic techniques. Of these isolates, compound 4, and the known compounds, nitidulin (6), amorphigenin (7), and dabinol (8), exhibited cytotoxic activity when evaluated against a small panel of human cancer cells. Nitidulin (6) was further tested in an in vivo hollow fiber assay, and found to be active against LNCaP (human hormone-dependent prostate cancer) cells implanted intraperitoneally, at doses of 10, 20, and 40 mg/ kg.	en_GB
dc.language.iso	en	en_GB
dc.publisher	NIH Public Access	en_GB
dc.relation.ispartofseries	Journal of Natural Products;
dc.subject	Prenylated	en_GB
dc.subject	Flavonoids	en_GB
dc.subject	Root Bark	en_GB
dc.subject	Berchemia	en_GB
dc.subject	Tanzanian Medicinal Plant	en_GB
dc.title	Prenylated Flavonoids from the Root Bark of Berchemia discolor, a Tanzanian Medicinal Plant	en_GB
dc.type	Article	en_GB