HPLC analysis of anti-malaria agent, chloroquine in blood and tissue from forensic autopsy cases in Tanzania

Yonemitsu, K.; Koreeda, A.; Kibayashi, K.; Ng’walali, P.; Mbonde, M.; Kitinya, J.; Tsunenari, S.

dc.contributor.author	Yonemitsu, K.
dc.contributor.author	Koreeda, A.
dc.contributor.author	Kibayashi, K.
dc.contributor.author	Ng’walali, P.
dc.contributor.author	Mbonde, M.
dc.contributor.author	Kitinya, J.
dc.contributor.author	Tsunenari, S.
dc.date.accessioned	2013-02-15T09:28:12Z
dc.date.available	2013-02-15T09:28:12Z
dc.date.issued	2005
dc.identifier.issn	2004.10.002
dc.identifier.uri	http://hdl.handle.net/123456789/481
dc.description.abstract	HPLC analysis of anti-malaria agent, chloroquine (CQ) in blood and tissues with a simple HCl back extraction method was applied to three forensic autopsy cases in Dar es Salaam, Tanzania. CQ concentrations in femoral vein blood were 8.5, 48.4 and 43.8 mg/ml in three cases, respectively, which were high enough to attribute the cause of deaths to an acute CQ poisoning. There were great site dependent variations in blood CQ levels. The right heart blood samples were very high, which may be explained by incomplete distribution of the drug before death or postmortem diffusion from liver and its surrounding blood, as high CQ levels were remarkable in the liver. Suicidal and accidental CQ poisonings are very common and CQ is a very important chemical in the field of forensic toxicology in Tanzania.	en_GB
dc.language.iso	en	en_GB
dc.publisher	ELSEVIER	en_GB
dc.relation.ispartofseries	Legal Medicine 7 (2005) 113–116
dc.subject	Chloroquine	en_GB
dc.subject	HPLC	en_GB
dc.subject	Tissue distribution	en_GB
dc.subject	Acute poisoning	en_GB
dc.subject	Tanzania	en_GB
dc.title	HPLC analysis of anti-malaria agent, chloroquine in blood and tissue from forensic autopsy cases in Tanzania	en_GB
dc.type	Article	en_GB