• Ethnomedical survey of plants used for the management of HIV and AIDS-related conditions in Mbulu District, Tanzania 

  Marealle, A; Moshi, M; Innocent, E; Qwarse, M; Marobela, K (2020-12-08)

  The aim of this Study was to document medicinal plants used in the management of HIV and AIDS related conditions in Mbulu District. An ethnomedical survey was conducted using a semi-structured questionnaire. The main HIV ...
• Advancing Pharmacy Practice in Tanzania: A Descriptive Report of Pharmacy Education and Practice Models in 3 Institutions 

  Mbilinyi, C; Buma, , D; Ngasa, S; Maingu, R; Maganda, B; Kaali, W; Uledi, M; Mkinga, , B; Njonjo, B; Amiri, J; . Zuckerman, A (INQUIRY, 2021-11-09)

  Abstract Understanding models of pharmacy education and practice in low-to-middle income countries (LMIC) can drive best practices and resource utilization. However, there is a paucity of literature in this setting. The ...
• Usage of Oral Rehydration Salts and Other Treatments in Management of Diarrhoea Among Children Under-Five Years Attending Primary Health Care Facilities in Dar es Salaam TMJ Origin 

  Mutagonda, R; Kilonzi, M; Mikomangwa, W, P; Mlyuka, H (Tanzania Medical Journal, 2020)

  Background Diarrhoeal disease is highly preventable and easily manageable, yet it remains a significant cause of childhood mortality in Tanzania. Since dehydration caused by acute diarrhoea is the main contributor to ...
• Quality of selected anti-retroviral medicines: Tanzania Mainland market as a case study 

  Mziray, S.; Maganda, B. A.; Mwamwitwa, K.; Fimbo, A. M.; Kaale, E.; Mwalwisi, Yonah H. (BMC Pharmacology and Toxicology, 2021)

  Background: Antiretroviral drugs (ARVs) have significantly reduced morbidity, mortality and improved the quality of life of people living with HIV infection. Poor quality ARVs may result in harmful consequences such as ...
• Quality monitoring of anti-TB drugs in Tanzania, 2012-2018 

  Mwamwitwa, T. W.; Maganda, B. A.; Kisense, S.; Mziray, S. A.; Kaale, E. (Tropical Medicine and Surgery, 2021)

  Background: The use of substandard and falsified (SF) anti-tuberculosis (ANT-TB) drugs may lead to treatment failure and the development of drug resistance. It is claimed that SF medicinal products are more prevalent in ...
• Effect of Dihydroartemisinin-Piperaquine on the Pharmacokinetics of Praziquantel for Treatment of Schistosoma mansoni Infection 

  Minzi, O. M; Mnkugwe, R. H.; Ngaimisi, E.; Kinung’hi, S.; Hansson, A.; Pohanka, A; Kamuhabwa, A.; Aklillu, E. (MDPI-Pharmaceuticals, 2021)

  Praziquantel (PZQ) and dihydroartemisinin-piperaquine (DHP) combination recently showed superior effectiveness than PZQ alone to treat intestinal schistosomiasis. In this follow-up study, we investigated the effect of ...
• Preformulation Studies for Generic Omeprazole Magnesium Enteric Coated Tablets: Advance Study 

  Migoha, C. O.; Ratansi, M.; Kaale, E.; Kagashe, G. (Issues and Development in Health Research, 2021)

  Preformulation is an important step in the rational formulation of an active pharmaceutical ingredient (API). Micromeritics properties: bulk density (BD) and tapped density (TD), compressibility index (Carr’s index), ...
• Effectiveness of Intermittent Preventive Treatment With Dihydroartemisinin Piperaqunine Against Malaria in Pregnancy in Tanzania: A Randomized Controlled Trial 

  Mlugu, E. M.; Minzi, O.; Kamuhabwa, A. A. R.; Aklillu, E. (Clinical Pharmacology & Therapeutics, 2021)

  Intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) to prevent malaria and adverse birth outcomes is threatened by Plasmodium falciparum resistance to sulfadoxine-pyrimethamine. We ...
• The Existence of High Bacterial Resistance to Some Reserved Antibiotics in Tertiary Hospitals in Tanzania: A Call to Revisit Their Use 

  Mikomangwa, W. P.; Bwire, G. M.; Kilonzi, M.; Mlyuka, H.; Mutagonda, R. F.; Kibanga, W.; Marealle, A. I.; Minzi, O.; Mwambete, K. D. (Infection and drug resistance, 2021)

  Background: Antibiotic resistance poses burden to the community and health-care services. Efforts are being made at local, national and global level to combat the rise of antibiotic resistance including antibiotic ...
• Optimal single sampling time‑point for monitoring of praziquantel exposure in children 

  Mnkugwe, R. H.; Kitabi, E. N.; Kinung’hi, S.; Kamuhabwa, A. A. R.; Minzi, O. M.; Aklillu, E. (Scientific Reports, 2021)

  Praziquantel pharmacokinetics studies in schistosomiasis infected children are scarce partly due to the challenges/complexity of intensive blood sampling in the target population. This study was aimed to investigate ...
• Knowledge on utilization of wild mushrooms by the local communities in the Selous-Niassa Corridor in Ruvuma Region, Tanzania 

  Qwarse, M.; Moshi, M.; Mihale, M. J.; Marealle, A. I.; Sempombe, J.; Mugoyela, V. (Journal of Yeast and Fungal Research, 2021)

  The present study focused on documentation of wild mushroom species used by the local communities in the Selous-Niassa corridor in Namtumbo district, Ruvuma region, Tanzania. Qualitative and quantitative data were ...
• Possible vertical transmission and antibodies against SARS‐CoV‐2 among infants born to mothers with COVID‐19: A living systematic review 

  Bwire, G,M; Njiro, B,J; Mwakawanga, D,L; Sabas, D; Sunguya, B,F (Journal of medical virology, 2020)

  Abstract Current evidence suggests that coronavirus disease 2019 (COVID‐19), caused by severe respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is predominantly transmitted from human‐to‐human. However, evidence on ...
• Detection profile of SARS‐CoV‐2 using RT‐PCR in different types of clinical specimens: A systematic review and metaanalysis 

  Bwire, G,M; Majigo, M,V; Njiro, B,J; Mawazo, A (jurnal of medical virology, 2020)

  Testing is one of the commendable measures for curbing the spread of coronavirus disease (COVID‐19). But, it should be done using the most appropriate specimen and an accurate diagnostic test such as real‐time reverse ...
• Optimal management of esophageal cancer in Africa: A systemic review of treatment strategies 

  Buckle, G, C; Mahapatra, R; Akoko, L; Mmbaga, E,J; White, R,E; Bent, S; Loon, K,V (CANCER EPIDEMIOLOGY, 2020)

  Esophageal cancer (EC) is a leading cause of cancer morbidity and mortality in Africa. Despite the high burden of disease, optimal management strategies for EC in resource-constrained settings have yet to be established. ...
• Perspectives on Building Sustainable Newborn Screening Programs for Sickle Cell Disease: Experience from Tanzania 

  Bukini, D; Nkya, S; McCurdy, S; Mbekenga, C; Manji, K; Parker, M; Makani, J (Int. J. Neonatal Screen, 2021)

  Abstract: The prevalence of sickle cell disease is high in Africa, with significant public health effects on the affected countries. Many of the countries with the highest prevalence of the disease also have poor health ...
• Comparative Assessment of the Pharmacovigilance Systems within the Neglected Tropical Diseases Programs in East Africa—Ethiopia, Kenya, Rwanda, and Tanzania 

  Barry, A; Olsson, S; Khaemba, C; Kabatende, J; Dires, T; Fimbo, A; Minzi, O; Bienvenu, E; Makonnen, E; Kamuhabwa, A; Oluka, M; Guantai, A; Puijenbroek, E; Bergman, U; Nkayamba, A; Mugisha, M; Gurumurthy, P; Aklillu, E (Int. J. Environ. Res. Public Health, 2021)

  Abstract: Monitoring the safety of medicines used in public health programs (PHPs), including the neglected tropical diseases (NTD) program, is a WHO recommendation, and requires a wellestablished and robust pharmacovigilance ...
• Neuropsychiatric manifestations among HIV-1 infected African patients receiving efavirenz-based cART with or without tuberculosis treatment containing rifampicin 

  Mugusi, S; Ngaimisi, E.; Mugusi, F.; Minzi, O; Aris, E.; Bertilsson, L.; Burhenne, J.; Sandstrom, E.; Aklillu, E.; Anabi, M. (Springer, 2018)

  Purpose Efavirenz-based combination antiretroviral therapy (cART) is associated with neuropsychiatric adverse events. We investigated the time to onset, duration, clinical implications, impact of pharmacogenetic variations, ...
• Comparative assessment of the magnitude of Hyperlipidemia in HIV-Infected patients receiving Lopinavir/r- and Atazanavir/r-Based Antiretroviral drugs 

  Muya, E.; Kamuhabwa, A. (Sage, 2019)

  Objective: To assess prevalence of hyperlipidemia in patients receiving lopinavir boosted with ritonavir (LPV/r) and atazanavir boosted with ritonavir (ATV/r) antiretroviral drugs. Methods: HIV-infected patients (300) ...
• Immunoglobulin G responses against falciparum malaria specific antigens are higher in children with homozygous sickle cell trait than those with normal hemoglobin 

  Bwire, G.M.; Majigo, M,; Makalla, R; Nkinda, L; Mawazo, A; Mizinduko, M,; Makani, J, (Springer Nature, 2019)

  Abstract Background: High Immunoglobulin G (IgG) response to Plasmodium falciparum antigens is associated with partial malaria protection in sickle hemoglobin (HbS) children. However, this response has been more studied ...
• Level of knowledge among health care providers on preparation of injectable artesunate for treatment of severe malaria in public health facilities in Tanzania 

  Mikomangwa*, W,P.; Kaaya, C; Kilonzi, M; Mlyuka, H; Marealle, A,I; Mutagonda, R (BMC, 2019)

  Abstract Objective: In Tanzania, seminars and training on the preparation and administration of injectable artesunate were given to health care providers (HCP) during its introduction in 2013. Published evidence on ...

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