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Antibacterial and cytotoxic triterpenoids from ! " ssp. ! " var. # "

Innocent, Ester; Moshi, Mainen J.; Shah, Tinah; Nondo, Ramadhani S.O. (2011)

BACKGROUND: ssp. var. is used in traditional medicine as a mosquito repellent and sometimes chewed for treatment of gastrointestinal problems. Gastrointestinal problems are ...

Antibacterial and cytotoxic activities of Terminalia stenostachya and Terminalia spinosa

Mbwambo, Z.H.; Kidukuli, A.W.; Erasto, P.; Innocent, E.; Nondo, R.O.S. (2011)

Plants that belong to the Combretaceae family have long history of use in the traditional medicine systems of Africa and Asia for treatment of diseases and conditions associated with HIV/AIDS-opportunistic infections. ...

Anti-Mycobacterial and Toxicity Activities of Some Priority Medicinal Plants from Lake Victoria Basin, Tanzania

Magadula, Joseph J.; Otieno, Joseph N.; Nondo, Ramadhani S.; Kirimuhuzya, Claude; Kadukuli, E.; Orodho, John A. (2012)

Aims: This study has evaluated ethanol extracts from five medicinal plants selected through ethnobotanical study from Lake Victoria basin, Tanzania for their in vitro antimycobacterial activity against two Mycobacterium ...

Role of traditional healers in the management of severe malaria among children below five years of age: the case of Kilosa and Handeni Districts, Tanzania.

Makundi, E.A.; Malebo, H.M.; Mhame, P.; Kitua, A.Y,; Warsame, M. (2006)

BACKGROUND: The current malaria control strategy of WHO centres on early diagnosis and prompt treatment using effective drugs. Children with severe malaria are often brought late to health facilities and traditional ...

Molecular surveillance of drug-resistance associated mutations of Plasmodium falciparum in south-west Tanzania.

Schönfeld, M; Barreto Miranda, I; Schunk, M; Maduhu, I; Maboko, L; Hoelscher, M.; Berens-Riha, N.; Kitua, A.; Löscher, T. (2007)

BACKGROUND: In Tanzania, drug-resistant malaria parasites are an increasing public health concern. Because of widespread chloroquine (CQ) resistance Tanzania changed its first line treatment recommendations for uncomplicated ...

The magnitude and factors associated with delays in management of smear positive tuberculosis in Dar es Salaam, Tanzania.

Mfinanga, S.G.; Mutayoba, B.K.; Kahwa, A.; Kimaro, G.; Mtandu, R.; Ngadaya, E.; Egwaga, S.; Kitua, A.Y. (2008)

OBJECTIVE: To assess the magnitude and factors responsible for delay in TB management. DESIGN: A cross sectional hospital based survey in Dar es Salaam region, May 2006. RESULTS: We interviewed 639 TB patients. ...

Malaria and mosquito net utilisation among schoolchildren in villages with or without healthcare facilities at different altitudes in Iringa District, Tanzania.

Mboera, L.E.; Kamugisha, M.L.; Rumisha, S.F.; Kisinza, W.N.; Senkoro, K.P.; Kitua AY, A.Y. (2008)

BACKGROUND: The endemicity of malaria in Tanzania is heterogenous, mainly associated with physical factors such as topography, climate and socio-economic status. The contributions of these factors in many regions of ...

To what extent can traditional medicine contribute a complementary or alternative solution to malaria control programmes?

Graz, B.; Kitua, A.Y.; Malebo, H.M. (2011)

Recent studies on traditional medicine (TM) have begun to change perspectives on TM effects and its role in the health of various populations. The safety and effectiveness of some TMs have been studied, paving the way to ...

Coordinating health research to promote action: the Tanzanian experience.

Kitua, A.Y.; Mashalla, Y.J.; Shija, J.K. (2000)

Malaria morbidity and immunity among residents of villages with different Plasmodium falciparum transmission intensity in North-Eastern Tanzania

Lusingu, J.P.; Vestergaard, L.S.; Mmbando, B.P.; Drakeley, C.J.; Jones, C.; Akida, J.; Savaeli, Z.X.; Kitua, A.Y.; Lemnge, M.M.; Theander, T.G. (2004)

BACKGROUND: The relationship between the burden of uncomplicated malaria and transmission intensity is unclear and a better understanding of this relationship is important for the implementation of intervention ...

Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study.

Reyburn, H.; Mbatia, R.; Drakeley, C.; Carneiro, I.; Mwakasungula, E.; Mwerinde, O.; Saganda, K.; Shao, J.; Kitua, A.; Olomi, R.; Greenwood, B.M.; Whitty, C.J. (2004)

OBJECTIVE: To study the diagnosis and outcomes in people admitted to hospital with a diagnosis of severe malaria in areas with differing intensities of malaria transmission. DESIGN: Prospective observational study ...

Intermittent preventive treatment of malaria during pregnancy: a qualitative study of knowledge, attitudes and practices of district health managers, antenatal care staff and pregnant women in Korogwe District, North-Eastern Tanzania.

Mubyazi, G.; Bloch, P.; Kamugisha, M.; Kitua, A.; Ijumba, J. (2005)

BACKGROUND: Intermittent preventive treatment of malaria during pregnancy (IPTp) is a key intervention in the national strategy for malaria control in Tanzania. SP, the current drug of choice, is recommended to be ...

Creating an "enabling environment" for taking insecticide treated nets to national scale: the Tanzanian experience.

Magesa, S.M.; Lengeler, C.; deSavigny, D.; Miller, J.E.; Njau, R.J.; Kramer, K.; Kitua, A.; Mwita, A. (2005)

INTRODUCTION: Malaria is the largest cause of health services attendance, hospital admissions and child deaths in Tanzania. At the Abuja Summit in April 2000 Tanzania committed itself to protect 60% of its population ...

Cytophilic antibodies to Plasmodium falciparum glutamate rich protein are associated with malaria protection in an area of holoendemic transmission.

Lusingu, J.P.; Vestergaard, L.S.; Alifrangis, M.; Mmbando, B.P.; Theisen, M.; Kitua, A.Y.; Lemnge, M.M.; Theander, T.G. (2005)

BACKGROUND: Several studies conducted in areas of medium or low malaria transmission intensity have found associations between malaria immunity and plasma antibody levels to glutamate rich protein (GLURP). This study ...

Triple-antiretroviral prophylaxis to prevent mother-to-child HIV transmission through breastfeeding--the Kisumu Breastfeeding Study, Kenya: a clinical trial.

Thomas, T.K.; Masaba, R.; Borkowf, C.B.; Ndivo, R.; Zeh, C.; Misore, A.; Otieno, J.; Jamieson, D.; Thigpen, M.C.; Bulterys, M.; Slutsker, L.; Amornkul, P.N.; Greenberg, A.E.; Fowler, M.G. (2011)

BACKGROUND: Effective strategies are needed for the prevention of mother-to-child HIV transmission (PMTCT) in resource-limited settings. The Kisumu Breastfeeding Study was a single-arm open label trial conducted between ...

Differential association of gene content polymorphisms of killer cell immunoglobulin-like receptors with placental malaria in HIV- and HIV+ mothers.

Omosun, Y.O.; Blackstock, A.J.; Gatei, W.; Hightower, A.; van Eijk, A.M.; Ayisi, J.; Otieno, J.; Lal, R.B.; Steketee, R.; Nahlen, B.; ter Kuile, F.O.; Slutsker, L.; Shi, Y.P. (2012)

Pregnant women have abundant natural killer (NK) cells in their placenta, and NK cell function is regulated by polymorphisms of killer cell immunoglobulin-like receptors (KIRs). Previous studies report different roles of ...

Anticonvulsant activity of Diospyros fischeri root extracts.

Moshi, M.J.; Mbwambo, Z.H.; Nondo, R.S.; Masimba, P.J.; Kapingu, M.C.; Magelewanya, E.S. (2007)

Diospyros fischeri Gurke (Ebenaceae) is used in traditional medicine for the treatment of epilepsy. Dichloromethane, ethylacetate, and ethanol extracts of the roots, at doses between 100 and 1600 mg/kg BW, inhibited ...

The efficacy of the crude root bark extracts of Erythrina abyssinica on rifampicin resistant Mycobacterium tuberculosis.

Bunalema, L.; Kirimuhuzya, C.; Tabuti, J.R.; Waako, P.; Magadula, J.J.; Otieno, N.; Orodho, J.A. (2011)

INTRODUCTION: Tuberculosis (TB) is one of the leading causes of morbidity and mortality with a global mortality rate at two million deaths per year while one third of the world's population is infected with the TB ...

Sputum microscopy for the diagnosis of HIV-associated pulmonary tuberculosis in Tanzania.

Matee, M.; Mtei, L.; Lounasvaara, T.; Wieland-Alter, W.; Waddell, R; Lyimo, J.; Bakari, M.; Pallangyo, K.; von Reyn, C.F. (2008)

BACKGROUND: In many resource poor settings only sputum microscopy is employed for the diagnosis of HIV-associated pulmonary tuberculosis; sputum culture may not be available. METHODS: We determined the diagnostic accuracy ...

Basis for treatment of tuberculosis among HIV-infected patients in Tanzania: the role of chest x-ray and sputum culture.

Bakari, M.; Arbeit, R.D.; Mtei, L.; Lyimo, J.; Waddell, R.; Matee, M.; Cole, B.F.; Tvaroha, S.; Horsburgh, C.R.; Soini, H.; Pallangyo, K.; von Reyn, C.F. (2008)

BACKGROUND: Active tuberculosis (TB) is common among HIV-infected persons living in tuberculosis endemic countries, and screening for tuberculosis (TB) is recommended routinely. We sought to determine the role of chest ...

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