A Monkey Model for Epstein Barr Virus-associated Lymphomagenesis in Human Acquired Immunodeficiency Syndrome

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dc.contributor.author Feichtinger, H.
dc.contributor.author Biberfeld, G.
dc.contributor.author Weyrer, K.
dc.contributor.author Böttiger, D.
dc.contributor.author Ernberg, I.
dc.contributor.author Linde, A.
dc.contributor.author Grünewald, K
dc.contributor.author Li, S.L.
dc.contributor.author Kaaya, E.
dc.contributor.author Putkonen, P.
dc.date.accessioned 2013-04-03T19:19:53Z
dc.date.available 2013-04-03T19:19:53Z
dc.date.issued 1992
dc.identifier.citation Feichtinger, H., Li, S. L., Kaaya, E., Putkonen, P., Grünewald, K., Weyrer, K., ... & Biberfeld, G. (1992). A monkey model for Epstein Barr virus-associated lymphomagenesis in human acquired immunodeficiency syndrome. The Journal of experimental medicine, 176(1), 281-286.
dc.identifier.other PMID: 1319458
dc.identifier.uri http://hdl.handle.net/123456789/780
dc.description.abstract High-grade malignant nonHodgkin's lymphomas-five lymphoblastic, three pleomorphic, and two immunoblastic-developed in 10/25 cynomolgus monkeys (Macacafascicularis) followed for up to 746 d after infection with simian immunodeficiency virus, strain SIVsm. These lymphomas were shown to be associated with an Epstein-Barr (EB)-like cynomolgus B-lymphotropic herpesvirus (CBLV) by electron microscopy, by Southern blot hybridization with probes against human EBV, and by the expression of antigens corresponding to EBV-associated nuclear antigens (EBNAs) involved in human B cell transformation. Southern blot demonstration ofimmunoglobulin gene rearrangements and homogeneous EBV episomes indicated that all the lymphomas were CBLVassociated monoclonal B cell proliferations. Our findings suggest that these tumors correspond to the EBV-associated malignant lymphomas in acquired immunodeficiency syndrome with respect to clinical, morphological, phenotypic, and genotypic characteristics. The particular susceptibility of SIVsm immunodeficient cynomolgus monkeys for CBLV-associated lymphomagenesis appears therefore a useful model for EBV-associated lymphomas in humans. en_GB
dc.language.iso en en_GB
dc.publisher The Rockefeller University
dc.relation.ispartofseries J. Exp. Med. 176(1):281-6.
dc.subject Monkey Model en_GB
dc.subject Epstein Barr en_GB
dc.subject Lymphomagenesis en_GB
dc.subject Human Acquired Immunodeficiency Syndrome en_GB
dc.title A Monkey Model for Epstein Barr Virus-associated Lymphomagenesis in Human Acquired Immunodeficiency Syndrome en_GB
dc.type Article en_GB


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