dc.contributor.author |
Feichtinger, H. |
|
dc.contributor.author |
Biberfeld, G. |
|
dc.contributor.author |
Weyrer, K. |
|
dc.contributor.author |
Böttiger, D. |
|
dc.contributor.author |
Ernberg, I. |
|
dc.contributor.author |
Linde, A. |
|
dc.contributor.author |
Grünewald, K |
|
dc.contributor.author |
Li, S.L. |
|
dc.contributor.author |
Kaaya, E. |
|
dc.contributor.author |
Putkonen, P. |
|
dc.date.accessioned |
2013-04-03T19:19:53Z |
|
dc.date.available |
2013-04-03T19:19:53Z |
|
dc.date.issued |
1992 |
|
dc.identifier.citation |
Feichtinger, H., Li, S. L., Kaaya, E., Putkonen, P., Grünewald, K., Weyrer, K., ... & Biberfeld, G. (1992). A monkey model for Epstein Barr virus-associated lymphomagenesis in human acquired immunodeficiency syndrome. The Journal of experimental medicine, 176(1), 281-286. |
|
dc.identifier.other |
PMID: 1319458 |
|
dc.identifier.uri |
http://hdl.handle.net/123456789/780 |
|
dc.description.abstract |
High-grade malignant nonHodgkin's lymphomas-five lymphoblastic, three pleomorphic, and
two immunoblastic-developed in 10/25 cynomolgus monkeys (Macacafascicularis) followed for
up to 746 d after infection with simian immunodeficiency virus, strain SIVsm. These lymphomas
were shown to be associated with an Epstein-Barr (EB)-like cynomolgus B-lymphotropic herpesvirus
(CBLV) by electron microscopy, by Southern blot hybridization with probes against human EBV,
and by the expression of antigens corresponding to EBV-associated nuclear antigens (EBNAs)
involved in human B cell transformation. Southern blot demonstration ofimmunoglobulin gene
rearrangements and homogeneous EBV episomes indicated that all the lymphomas were CBLVassociated
monoclonal B cell proliferations. Our findings suggest that these tumors correspond
to the EBV-associated malignant lymphomas in acquired immunodeficiency syndrome with respect
to clinical, morphological, phenotypic, and genotypic characteristics. The particular susceptibility
of SIVsm immunodeficient cynomolgus monkeys for CBLV-associated lymphomagenesis appears
therefore a useful model for EBV-associated lymphomas in humans. |
en_GB |
dc.language.iso |
en |
en_GB |
dc.publisher |
The Rockefeller University |
|
dc.relation.ispartofseries |
J. Exp. Med. 176(1):281-6. |
|
dc.subject |
Monkey Model |
en_GB |
dc.subject |
Epstein Barr |
en_GB |
dc.subject |
Lymphomagenesis |
en_GB |
dc.subject |
Human Acquired Immunodeficiency Syndrome |
en_GB |
dc.title |
A Monkey Model for Epstein Barr Virus-associated Lymphomagenesis in Human Acquired Immunodeficiency Syndrome |
en_GB |
dc.type |
Article |
en_GB |