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Anticonvulsant activity of Diospyros fischeri root extracts.

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dc.contributor.author Moshi, M.J.
dc.contributor.author Mbwambo, Z.H.
dc.contributor.author Nondo, R.S.
dc.contributor.author Masimba, P.J.
dc.contributor.author Kapingu, M.C.
dc.contributor.author Magelewanya, E.S.
dc.date.accessioned 2013-04-22T09:39:10Z
dc.date.available 2013-04-22T09:39:10Z
dc.date.issued 2007
dc.identifier.other PMID: 20162096
dc.identifier.uri http://hdl.handle.net/123456789/924
dc.description.abstract Diospyros fischeri Gurke (Ebenaceae) is used in traditional medicine for the treatment of epilepsy. Dichloromethane, ethylacetate, and ethanol extracts of the roots, at doses between 100 and 1600 mg/kg BW, inhibited convulsions induced by the gamma-aminobutyric acid type A (GABAa) receptor antagonist, pentylenetetrazole (PTZ), in a dose dependent manner. The extracts also exhibited low toxicity against brine shrimps giving LC(50) values between 45.4 and 95.4 microg/ml. These results provide evidence for the potential of D. fischeri extracts to treat absence seizures, especially given their seemingly innocuous nature. en_GB
dc.language.iso en en_GB
dc.relation.ispartofseries Afr J Tradit Complement Altern Med.2006;4(2):226-30.
dc.subject Anticonvulsant en_GB
dc.subject Anticonvulsant en_GB
dc.subject Fischeri en_GB
dc.title Anticonvulsant activity of Diospyros fischeri root extracts. en_GB
dc.type Article en_GB


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