Anticonvulsant activity of Diospyros fischeri root extracts.

Moshi, M.J.; Mbwambo, Z.H.; Nondo, R.S.; Masimba, P.J.; Kapingu, M.C.; Magelewanya, E.S.

dc.contributor.author	Moshi, M.J.
dc.contributor.author	Mbwambo, Z.H.
dc.contributor.author	Nondo, R.S.
dc.contributor.author	Masimba, P.J.
dc.contributor.author	Kapingu, M.C.
dc.contributor.author	Magelewanya, E.S.
dc.date.accessioned	2013-04-22T09:39:10Z
dc.date.available	2013-04-22T09:39:10Z
dc.date.issued	2007
dc.identifier.other	PMID: 20162096
dc.identifier.uri	http://hdl.handle.net/123456789/924
dc.description.abstract	Diospyros fischeri Gurke (Ebenaceae) is used in traditional medicine for the treatment of epilepsy. Dichloromethane, ethylacetate, and ethanol extracts of the roots, at doses between 100 and 1600 mg/kg BW, inhibited convulsions induced by the gamma-aminobutyric acid type A (GABAa) receptor antagonist, pentylenetetrazole (PTZ), in a dose dependent manner. The extracts also exhibited low toxicity against brine shrimps giving LC(50) values between 45.4 and 95.4 microg/ml. These results provide evidence for the potential of D. fischeri extracts to treat absence seizures, especially given their seemingly innocuous nature.	en_GB
dc.language.iso	en	en_GB
dc.relation.ispartofseries	Afr J Tradit Complement Altern Med.2006;4(2):226-30.
dc.subject	Anticonvulsant	en_GB
dc.subject	Anticonvulsant	en_GB
dc.subject	Fischeri	en_GB
dc.title	Anticonvulsant activity of Diospyros fischeri root extracts.	en_GB
dc.type	Article	en_GB