Assessment of antibacterial activities of different brands of ciprofloxacin tablets

Abstract

The present study was carried out to evaluate and compare the antibacterial susceptibility of bacteria to different brands of Ciprofloxacin tablets. The following three bacterial strains were used: Staphylococcus aureus [ATCC 25923], Escherichia coli [ATCC 25922] and Pseudomonas aeruginosa [ATCC 27853]. Standard commercial discs of definite potency are used as reference standard (Ciprofloxacin lug). The test products 500 mg tablets of the following brands: Ciprobay, Bactiflox, Ciprodenk, Ladinin, Cipron, Zindolin, Bactiflox, ladinin and Ciproflox. There was a slight increase in the ZI of different brand at different time interval. This means that the solubility of the drugs invitro is increasing with time which in turns increases the zone of inhibition. Ciprobay produced more consistent ZI as compared to other brands, while no significant (p<0.05) differences were observed among other brands in respect of ZI. All tested brands of Ciprofloxacin yielded ZI within the acceptable ranges (as per USP). However, there were significant differences among them.