Anticonvulsant activity of Diospyros fischeri root extracts.
| dc.contributor.author | Moshi, M.J. | |
| dc.contributor.author | Mbwambo, Z.H. | |
| dc.contributor.author | Nondo, R.S. | |
| dc.contributor.author | Masimba, P.J. | |
| dc.contributor.author | Kapingu, M.C. | |
| dc.contributor.author | Magelewanya, E.S. | |
| dc.date.accessioned | 2013-04-22T09:39:10Z | |
| dc.date.available | 2013-04-22T09:39:10Z | |
| dc.date.issued | 2007 | |
| dc.description.abstract | Diospyros fischeri Gurke (Ebenaceae) is used in traditional medicine for the treatment of epilepsy. Dichloromethane, ethylacetate, and ethanol extracts of the roots, at doses between 100 and 1600 mg/kg BW, inhibited convulsions induced by the gamma-aminobutyric acid type A (GABAa) receptor antagonist, pentylenetetrazole (PTZ), in a dose dependent manner. The extracts also exhibited low toxicity against brine shrimps giving LC(50) values between 45.4 and 95.4 microg/ml. These results provide evidence for the potential of D. fischeri extracts to treat absence seizures, especially given their seemingly innocuous nature. | en_GB |
| dc.identifier.other | PMID: 20162096 | |
| dc.identifier.uri | http://hdl.handle.net/123456789/924 | |
| dc.language.iso | en | en_GB |
| dc.relation.ispartofseries | Afr J Tradit Complement Altern Med.2006;4(2):226-30. | |
| dc.subject | Anticonvulsant | en_GB |
| dc.subject | Anticonvulsant | en_GB |
| dc.subject | Fischeri | en_GB |
| dc.title | Anticonvulsant activity of Diospyros fischeri root extracts. | en_GB |
| dc.type | Article | en_GB |