No evidence of SARS-CoV-2 transmission through transfusion of human blood products: A systematic review

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dc.contributor.authorMawalla, W
dc.contributor.authorNjiro, B
dc.contributor.authorBwire, G
dc.contributor.authorNasser, A
dc.contributor.authorSunguya, B
dc.date.accessioned2023-08-10T08:26:59Z
dc.date.available2023-08-10T08:26:59Z
dc.date.issued2021-07
dc.description.abstractAbstract The presence of viral nucleic material in the circulation poses a theoretical risk of transmission through transfusion. However, little is known about the possibility of the actual transmission through transfusion or transplantation of blood products. A PROSPERO registered systematic review pooled evidence from PubMed/MEDLINE, Google Scholar and CINAHL. The search included studies on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission through human blood products. In total 537 studies were extracted, and only eight articles (1.5%) were eligible for the final analysis. A total of 14 patients received blood products from coronavirus disease 2019 (COVID-19) virus-positive donors, and six (42.9%) tested negative for COVID-19 RT-PCR for up to 14 days post-transfusion/transplantation. There were no docu mented clinical details on the COVID-19 test for eight (57.1%) blood products recipi ents. Of the eight patients, none of them developed any COVID-19-related symptoms. In conclusion, there is limited evidence of transfusion transmission of SARS-CoV-2 via human blood products. Consolidation of further evidence, as it emerges, is warranted.en_US
dc.identifier.citationMawalla, W.F., Njiro, B.J., Bwire, G.M., Nasser, A. and Sunguya, B., 2021. No evidence of SARS‐CoV‐2 transmission through transfusion of human blood products: A systematic review. EJHaem, 2(3), pp.601-606.Mawalla, W.F., Njiro, B.J., Bwire, G.M., Nasser, A. and Sunguya, B., 2021. No evidence of SARS‐CoV‐2 transmission through transfusion of human blood products: A systematic review. EJHaem, 2(3), pp.601-606.en_US
dc.identifier.urihttp://dspace.muhas.ac.tz:8080/xmlui/handle/123456789/3391
dc.language.isoenen_US
dc.publisherejHaernen_US
dc.relation.ispartofseriesEJHaem, 2(3), pp.601-606.;2(3),pp.601-606
dc.subjectKEYWORDS blood, blood products, bone marrow, covid-19, haematopoietic stem cells, SARS-CoV-2, transfusion, transmissionen_US
dc.titleNo evidence of SARS-CoV-2 transmission through transfusion of human blood products: A systematic reviewen_US
dc.typeArticleen_US

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Abstract The presence of viral nucleic material in the circulation poses a theoretical risk of transmission through transfusion. However, little is known about the possibility of the actual transmission through transfusion or transplantation of blood products. A PROSPERO registered systematic review pooled evidence from PubMed/MEDLINE, Google Scholar and CINAHL. The search included studies on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission through human blood products. In total 537 studies were extracted, and only eight articles (1.5%) were eligible for the final analysis. A total of 14 patients received blood products from coronavirus disease 2019 (COVID-19) virus-positive donors, and six (42.9%) tested negative for COVID-19 RT-PCR for up to 14 days post-transfusion/transplantation. There were no docu mented clinical details on the COVID-19 test for eight (57.1%) blood products recipi ents. Of the eight patients, none of them developed any COVID-19-related symptoms. In conclusion, there is limited evidence of transfusion transmission of SARS-CoV-2 via human blood products. Consolidation of further evidence, as it emerges, is warranted.
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